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ON GOING PROJECTS
AdvoCare
International:
(i) "Metabolic, Organoprotective,
Genomic and Non-Genomic
Effects of Thermoplus on Fisher 344 Rats"
(ii) "Long-Term
Exposure Effects of Metabolic Nutrition System-Platinum in B6C3F1
Mice"
ChoSeon Pharmaceuticals:
(i) "Long Term Exposure Effects of "WH" on Cerebral Apoplexy,
and Cardioprotective Activity in rats.
NY Methodist Hospital/AMS
Coll. of Pharmacy Collaboration:
Title- “Examining the
bicarbonate-chloroprocaine interactions with or without epinephrine in a sciatic nerve
block.” A collaborative research suppo. by
New York
Methodist Hospital.
aaaaaaaaaaaaaaaaaaaaaaaaa
PAST AWARDS
USDA:
"Designing Foods For Health: Antitoxic Properties of Flavonoids".
(i) Title-
"Effect of Long Term Exposure of MNS-Orange on Multiple Target Organs in
B6C3F1 Mice". Date: Jan, 2002 thru Dec, 2003. [Supp. By AdvoCare
International, Carrolton, TX.]
(ii) Title-
"Effect of Long Term Exposure of Grape Seed Proanthocyanidin Extract
on Prolongation of Life Span and Aging in Rodents". Date: Jan, 2000 thru
June, 2002. [Supp. By InterHealt, CA]
(iii) Title-
"Influence of long term Grape Seed Proanthocyanidin preexposure on
Dimethylnitrosamine-Induced Liver Cancer". Date: Sept, 99 thru June, 2002
[Supp. By InterHealth, CA]
(iv) Title-
"Effects of Peptobismol, High fat, alcoholic and Spicy diet Exposures on
Human GI tract". [1999-2001].
[Funded by Proctor & Gamble]
(v) Title-
"Effect of Grape Seed Proanthocyanidin preexposure on Amiodarone (lung),
Doxorubicin (heart), DMN (spleen), CdCl2 (kidney) and MOCAP (neuro: brain)
induced toxicities". [Dec, 1998 thru
Dec, 2000] [Supp. By InterHealth International, CA]
[Funded
by InterHealth, CA]
(vi) Title-
"Effect of Grape Seed Proanthocyanidin
preexposure on Acetaminophen-induced programmed and unprogrammed cell death
and bcl-XL expression in the liver". [Dec,
1996 thru Dec, 1998] [Funded
by InterHealth, CA]
(vii) Title-
"Acetaminophen-induced production of Nitric Oxide in the liver and its
protection by 3-Aminobenzamide". Supp. by American Academy
of Clinical Toxicology (National Research Award). [1995-1996].
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ACTIVE ONGOING RESEARCH PROJECTS
1. Genomic, Non-Genomic and Organotoxic effects of ThermoPlus
in Rats.
2. Effects of "WH" on induced cerebral apoplexy and other cardiovascular
disorders in rats.
3. Antitoxic properties of Limonoids in vivo.
4. Effects of Long Term Chronic Exposure effects of a complex Metabolic
Nutrition System on Serum Chemistry, Oxidative Stress in target
organs and Organ Histopathology in Mice.
5. Effects of Long Term Chronic Exposure of MNS-Orange on
Serum Chemistry, Organ Histopathology and Genomic/Non-Genomic changes in
multiple vital target organs in Mice (AdvoCare).
6. Mechanisms underlying Antiapoptotic and Antinecrotic properties of Grape Seed Proanthocyanidins,
Citrus flavonoids, Momordica Charantia falvonoids, Ocimum basilicum
flavonoids in vivo.
7. Role of Matrix Metallo Proteinases (MMPs -9, -10 & -12) during
dimethylnitrosamine (DMN)-induced liver cell death.
8. Role of Matrix Metallo Proteases (MMPs) and Mdm2 during dimethylnitrosamine (DMN)-induced nephrotoxicity
in mice.
9. Effects of flavonoids on CYP450IIE1 and CYP3A4 isozymes of the
mouse liver: Structure Activity Relationships.
PHARM.D. RESEARCH PROJECTS
( 1)
1994: Ms. Lana
Shleyfer: Protection of Acetaminophen-induced hepato- & nephrotoxicities by
cytoprotective agents.*
(2)
1995:
Ms. Amita Rana: Role of Nitric oxide in acetaminophen-induced hepatotoxicity.
(3)
1996:
Mr. Anup Wattamar: Drug-Induced programmed and unprogrammed cell death
mechanisms.*
(4) Ms. Theodora Manolas: Alcohol-Induced Liver Cell
apoptosis in normal and Spontaneously hypertensive rats.**
(5)
1997:
Ms. Suzana Bogdanovic: Furosemide-Induced Hepatocellular apoptosis in in
vivo models.**
(6) Ms. Agniska Dobrogoskya: Furosemide-Induced
nephrotoxicity and DNA damage in in vivo models.**
(7) Mr. Amit Khandar: Furosemide toxicity and their
protection by Ca++-channel blockers and PARP inhibitors.
(8)
1998:
Ms. Vermone Wong: Doxorubicin-Induced cardiotoxicity/mechanisms/MOCAP-induced
neurotoxicity mechanisms.**
(9) Mr. Kevin Fu:
Doxorubicin-Induced pulmonary toxicity
mechanisms.*
(10) Mr. Babak Kohanchi:
Doxorubicin-Induced
hepatotoxic mechanisms.*
(11) Ms. Anna Rinkovsky: Doxorubicin-Induced
hepatotoxicity/mechanisms/Effects of DMN on the liver cancer.*
(12)
1999:
Ms. Shelly Alli: Effect of antioxidants (basil extract, gourd extract) on
Thioacetamide-induced hepatotoxicity.*, ***
(13)
2000:
Ms. Hoyan Lee: Effects of Furosemide on Diabetic Liver (biochemical
changes).*
(14)
Ms. Inna Khantsis: Effects of Furosemide on
Diabetic Kidneys (biochemical changes).*
(15)
Ms. Christina Rutigliano: Effects of Furosemide
on DNA repair mechanisms in the liver.*,***
(16)
Ms. Jeny Kleyman: Effects of Furosemide on DNA
repair mechanisms in the Kidney.*
(17)
2001:
Mr. Oshaon Imafidon: Effects of Furosemide on Diabetic Liver (serum
chemistry).
(18)
Ms. Lyuba Alvarez: Effects of Furosemide on
Diabetic Kidney (Histopathological changes).
(19)
Ms. K. Kafui: Effects of antidiabetic agents on
Alloxan-Induced hepatomegaly and Nephropathy.
(20)
2002:
Ms. Carmela Bruculeri: Protection of Acetam. Liver
Injury By M. Charantia Extract-Histopathology analysis.*,**
(21) Ms. Agnes Chou: Protection of Acetaminophen
Liver Injury By M. Charantia Extract-DNA damage studies.***,*
(22) Ms. Switi Patel: Protection of Acetaminophen
Liver Injury By M. Charantia Extract-Serum Chemistry Analysis.*
(23) Mr. Ravi Patel: Protection of Acetaminophen
Liver Injury By M. Charantia Extract-Oxidative stress studies.*
(24)
2003:
Ms. Christina Wong: Xenobiotic Handling Capacity of
MNS-Orange exposed tissues.
(25) 2004:
Ms. Akila Nagori: Protection of APAP-induced liver injury by MNSO mixture. *
(26)
Ms. Annie Naqvi: Protection of APAP-induced
liver injury by MNSO mixture. *
(27) 2005:
Ms. Ellida Bulku: Protection of APAP-induced liver injury by curcumin
pre-exposure.*
(28)
Mr. Danniel Zinkovsky: Protection of
APAP-induced liver injury by curcumin pre-exposure.*
(29) 2006:
Ms. Zenepe Tocilla: Long term exposure effects of Thermoplus on serum
chemistry of F344 Rats.*
(30)
Ms. Rositsa Genova: Long term exposure effects
of Thermoplus on organ pathology of F344 Rats.*
(31)
Ms. Michelle Garrison: Long term exposure
effects of Thermoplus on serum chemistry & organ pathology of F344 Rats.*
[**Recipients
of West Virginia Univ./Merck
Undergraduate National Research Symposium Award; *Data presented at the
Natl. meetings; co-authored peer-reviewed abstracts and/or publications; ***
Shirley Krauss Research Award Winner/Gordon Research Conference Travel Award
Recipients]
~~~~~~~~~~~~~~~~~~~~
Seminars Presented at Various Institutions
1.
M. D. Anderson Cancer Research Center,
TX,
1988.
2.
Univ. of
Miss. Medical Center,
Jackson, MS,
1989.
3.
Miss.
Academy of Sciences,
Jackson, MS,
1988 and 1989.
4. Univ. of New Mexico Coll. of
Pharmacy, ALBQ, NM, 1989, 1990, 1991; P & G Co, Cincinnati, OH, 1990.
5.
Rutgers
University, EOHSI,
Busch Campus,
NJ.
1991, 1993.
6. Albert Einstein School of
Medicine, New York, 1992; & Procter & Gamble,
Cincinnati, Ohio, 1991, 1992.
7.
Purdue
University,
West Lafayette,
IN, 1992;
Richardson Vicks R&D, Connecticut,
1993.
8.
Natl.
Center for Toxicological Res.
(NCTR),
Jefferson,
AR,
1993/ Sandoz Pharmaceuticals, NJ, 1993.
9. National Cancer Institute,
Frederick, MD, 1993; Ciba-Geigy Pharmaceuticals,
NJ, 1993.
10. Medical Coll. of Virginia,
Dept. of Pathology, Opening Grand Rounds, Jan 1994.
11.
Creighton
University
College of
Pharmacy, Toxicology Program,
Omaha,
NE,
Spring-1995.
12.
University of
Iowa,
College of
Veterinary Medicine,
Toxicology Program,
Ames,
IA.
Spring-1995.
13.
University of Missouri,
Colombia,
MO. Spring-1995.
14.
University of
Sciences at
Philadelphia (PCPS),
October, 2002.
15.
Cornell
University’s
Graduate Program in Molecular & Env. Toxicology,
(Ithaca,
NY),
November, 2002.
16.
European Convention Center,
Luxembourg,
Jan 31, 2003.
17.
Institute of ArbeitPhysiologie/MaxPlank
Institute,
Dortmund,Germany,
Feb, 2003.
18. Dept. of Biology, Long Island
University,
Brooklyn,
NY,
April-2003.
19. Division of Biological
Sciences, Ravishankar
University,
Raipur,
India,
August-2003.
20. Division of Molecular Biology,
College
of Pharmacy,
Seoul National Univ., Seoul, S.
Korea-Nov-2003.
21.
Univ. of Colorado
Health
Sciences Center,
College of
Pharmacy,
Sept-2004.
22.
Wayne
State
University,
Eugene & Applebaum Pharm. Sciences
Program,
Detroit,
MI,
Oct-2004.
23. Division of Biochemistry &
Molecular Biology, Univ.
of Windsor,
Windsor,
Canada,
Oct-2004.
24. R & D Institute
of Basic science Research, ChoSeon Pharma, South Korea, 2006.
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===========================================================================
Biennial
Abraham Krasnoff
Memorial Award for Lifetime Scholarly Achievement Ceremony,
April
24, 2008
[Formerly Trustees Award for Scholarly Achievement; TASA]
 
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